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Each TCP packet contains the starting sequence number of the data in that packet, and the sequence number called the acknowledgment number. of the last byte received from the remote peer. With this information, a sliding window protocol is implemented, as illustrated in Figure 7.28. The sending window, as shown in Figure 7.28 a., which is always upper-bounded by the newly ad ertised window rwnd. from the receiver, basically consists of sequence numbers for bytes that were sent but haven t been acknowledged and bytes that can be sent immediately. The sequence numbers for the first set of bytes are located at the left side of the window the sequence numbers are contiguous and increasing, unless wrapped around due to finite-bit overflow., while those for the second set of bytes are at the right side of the window. The sending window can shrink either from the left side wif, for example, an ACK numbered 5 is received, indicating that two bytes with sequence numbers 3 and 4 have been correctly received, as shown in Fig. 7.28 b.x, or from the right side wif an advertised window, e.g., rwnd s 3, is received and has size less than that of the current sending window 4., as shown in Fig.

In addition to the identi cation of potential targets for drug development, identi cation of the basis for individual differences in response to pharmacologic agents provides the framework for the much-discussed potential to practice individualized medicine In the simpler cases described above, the lack of drug ef cacy or the presence of toxic reactions to a drug in speci c individuals will be due to the existence of a small number of variants in a few well-de ned genes Available molecular and biochemical technology, coupled with knowledge of the genetic basis for the aberrant response, makes it feasible to identify hyper- and hyporesponding individuals for a small number of agents Unfortunately, individualizing treatment is currently feasible for only a small number of protocols.

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The availability of different formats also depends on other libraries you have installed (such as zlib for compression).

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The problem of identifying the molecular basis for aberrant responses is more complex when the response is the consequence of genetic variation in a number of different genes, with each variant having a relatively small impact on the functional capacity of the pathway or process It is also dif cult to de ne the phenotype and to develop diagnostic genotyping tests for these conditions with complex patterns of inheritance This is especially a problem when the deviation from the mean response is continuous and re ective of small contributions of multiple genes and multiple variants It has been suggested that knowledge of genetic variation will be useful information that can be incorporated at early stages of drug trials This has.

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When preparing an image for placement inside a drawing or page-layout document that will be printed to a PostScript output device, many artists prefer to save the image in the EPS format Converting the image to PostScript up front prevents the drawing or page-layout program from doing the work The result is an image that prints more quickly and with less chance of problems (Note that an image does not look any different when saved in EPS The idea that the EPS format somehow blesses an image with better resolution is pure nonsense) A second point in the EPS format s favor is clipping paths As explained graphically at the end of 8, a clipping path defines a free-form boundary around an image When you place the image into an object-oriented program, everything outside the clipping path becomes transparent.

While some programs notably InDesign and PageMaker recognize clipping paths saved with a TIFF image, many programs acknowledge a clipping path only when saved in the EPS format Third, although Illustrator has remedied the problems it had importing TIFF images, it still likes EPS best, especially where screen display is concerned Thanks to the EPS file s fixed preview, Illustrator can display an EPS image on screen very quickly compared with other file formats And Illustrator can display an EPS image both in the preview mode and in the super-fast artwork mode So if you want to import an image into Illustrator, QuarkXPress, or another objectoriented program, your best bet is EPS On the downside, EPS is an inefficient format for saving images thanks to the laborious way that it describes pixels.

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